Persons with co-occurring mental and substance abuse disorders must address both issues in order to become fully rehabilitated. Some individuals take drugs or alcohol to alleviate symptoms of mental health complications, and some individuals take drugs which then, in turn, causes symptoms which mimic mental health issues, such as anxiety and depression. Addiction rehabilitation professionals know how to distinguish between the two, and can work with clients to appropriately treat real mental health conditions in tandem with any other substance abuse treatment that is done with the individual. This has proven to be effective in keeping people with mental health problems off of drugs and mentally stable and healthy.

Gays and Lesbians can sometimes have unique treatment needs when receiving substance abuse treatment. A specialized curriculum and treatment atmosphere which is conducive to the needs of gays and lesbians is obtainable at certain drug and alcohol treatment facilities across the nation which recognize the unique needs and challenges which gays and lesbians will encounter during treatment. Gay and lesbians can achieve full rehabilitation and recovery just like any other individual in treatment, however it can be beneficial for gays and lesbians to be in a supportive setting which doesn't judge them or alienate them due to their sexual preference.